Endocrine Abstracts

Introduction: The diffuse large B-cell lymphoma (DLBCL) is known as one of the most common lymphoma worldwide with the prevalence of 25 % of all of non-Hodgkin lymphoma cases [1], but it is very rearly observed in thyroid. Around 30 % of Clinical cases of the DLBCL appear from extranodal organs, the prognosis depends on the site of origin [2].Case: A 18-year-old man was admitted to endocrinologist, complaining with a palpable nodule in the front neck for...

Objective: Growth hormone (GH) and sex hormone replacement therapy (SHRT) are standard treatment for patients with Turner syndrome (TS) that enhances bone mineral density (BMD), puberty, and quality of life. We aimed to evaluate the efficacy of SHRT and GH on BMD in TS patients.Methods: Cross-sectional study was performed in LUHS Kauno Klinikos in 2014–2018. 27 females with TS were enrolled. BMD and Z score...

Background: Turner syndrome (TS) occurs in approximately 1 in 2500 live female births. The frequency of pregnancies in TS patients is 2-5%. However, these pregnancies are at high risk of recurrent miscarriage, malformations in the children and poor cardiovascular outcomes in pregnant TS females.Case presentation: A 34 year-old woman was diagnosed with TS (46XX/46Xr) at age 9. From 16 to 20 years old she was treated with sex hormone replacement therapy an...

Diabetic mothers have an increased risk for pregnancy (early pregnancy loss, polyhydramnios, pre-eclampsia, premature labor) and progression of diabetic complications. We present a case of the progression of diabetic-related complications including autonomic neuropathy (AN) which caused severe vomiting during pregnancy. A 27-year-old type 1 diabetic woman with pregnancy of 8 weeks gestational age (GW) was admitted to our hospital for glycemia and diabetic-related complications...

Introduction: 45,X karyotype is known to be related to more severe phenotype disorders, still comparative analysis of the karyotypes and phenotypes in Turner syndrome (TS) is difficult, even in the largest studies, mainly due to differences in patient‘s age and variability in the definition of clinical features (1). We aimed: to assess if monosomia in Turner syndrome patients is related to their cardiometabolic features.Methods: 75 females with conf...

Objectives: To evaluate sexual function in women with Turner syndrome (TS) in the relation with sex hormones.Methods: The study was undertaken in Lithuanian University of Health Sciences. 65 women with genetically confirmed TS (18–45 years) were enrolled and compared with 65 age-matched healthy controls. Sexual function was evaluated using The Female Sexual Function Index (FSFI). Risk for sexual dysfunction was defined as FSFI score ≤ 26.55. B...

Introduction: Women with Turner syndrome (TS) are known to be at risk of decreased BMD (dBMD). Sex hormone replacement therapy is crucial to ensure the proper BMD formation, although the dBMD remains a problem in TS.Aim: To investigate the prevalence of decreased bone mineralization and it’s association with hormone levels in TS.Subjects: Women with geneticaly confirmed TS aged ≥ 18 year.Methods: T...

Introduction: Aortic dilation (AD) is the life threating complication of Turner syndrome (TS). The reported prevalence of AD in TS various between 12 and 39%. Factors predicting enlargement of diameter of aorta (DA) are still under investigation.Aim: To assess the prevalence of AD in TS in Lithuanian population, to evaluate the possible predictors of AD development.Methods: Forty-three patients with TS aged ≥18 year were enro...

Introduction: Two major strategies can be used to verify the diagnosis of ascending aortic dilatation in Turner syndrome (TS): the diameter of the aorta adjusted for body surface area (BSA) can be estimated or the ratio of the ascending/descending aorta may be assessed.Aim: To identify the difference of the prevalence of ascending aortic dilatation in patients with Turner syndrome by measuring the diameter of the ascending aorta adjusted for BSA and by e...

Introduction: Turner syndrome (TS) is associated with specific physical features, as well as a particular neuropsychological profile and social and behavioral features. It is common practice in the case of TS to treat short stature with growth hormone preparations and to induce puberty with estrogens at an age as close to normal puberty as possible. Nevertheless results of some studies show that despite the treatment, some women with TS still experience psychosocial problems, ...